Exploration of genetic and epigenetic determinism of cell behavior using quantitative phase imaging

Quantitative analysis of changes in cell behavior induced by replacement of genetic material using DNA microinjection in vitro. Statistical significance of changes in cell behavior, such as speed of cell motility, will be evaluated using coherence-controlled holographic microscopy and other methods for quantitative phase imaging. Dynamic morphometric parameters will be measured using computer image processing methods. The project will involve microscopy techniques, cell culture, capillary microinjection, computer image processing and data analysis.

Supervisor: Daniel Zicha